2 edition of Synthesis of polyamines in rat tissues found in the catalog.
Synthesis of polyamines in rat tissues
by Department of Medical Chemistry, University of Helsinki in Helsinki
Written in English
Polyamines (PAs) are molecules involved in a variety of functions and present in a diverse set of organisms, from prokaryotes to plants to humans. There are a few common types of PAs and the particular species of PA, as well as its particular func. The cellular mechanisms controlling adaptive intestinal mucosal hypo- and hyperplasia are poorly understood but changes in tissue polyamine levels and in the activity of the key enzyme controlling their synthesis (ornithine decarboxylase: ODC) and degradation (diamine Cited by:
Protein Synthesis in the Developing Rat Liver: Participation of Initiation Factors eIF-2 and eIF-2B ANA M. GARC~A,~ M. ELENA MART~N,~ ALBERTO ALc~AR,~ JUAN L. FAN DO^ AND M. SALINAS' 'Biochemistry Service, Department of Investigation, Hospital Ramdn y Cajal, Madrid, and 'Department of Biochemistry and Molecular Biology, University of Alcala, Madrid, SpainCited by: 5. Polyamines (putrescine, spermidine, and spermine) are low M r polycations found in all living organisms. At the cellular level, polyamines are involved in DNA and protein synthesis, stabilization of membranes, scavenging of free radicals, and modulation of enzyme activities (Minocha and Minocha, ; Watson and Malmberg, , Walden et al., ; Kumar and Minocha, ).Cited by:
SUMMARY Polyamines are small, abundant, aliphatic molecules present in all mammalian cells. Within the context of the cell, they play a myriad of roles, from modulating nucleic acid conformation to promoting cellular proliferation and signaling. In addition, polyamines have emerged as important molecules in virus-host interactions. Many viruses have been shown to require polyamines Cited by: Plant polyamines are preferentially detected in actively growing tissues and under stress conditions and have been implicated in the control of cell division, embryogenesis, root formation, fruit development and ripening, and responses to biotic and abiotic stresses (Kumar et al., ).The molecular mechanism of how polyamines act in these processes had remained by:
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BIOCHIMICA ET BIOPHYSICA ACTA BBA POLYAlVIINES IN THE DEVELOPING RAT AND IN SUPPORTIVE TISSUES DIANE H. RUSSELL AND THOMAS A. McVICKER National Cancer Institute, National Institutes o/Health, Baltimore Cancer Research Center, Labora- ory o/ Pharmacology, Baltimore, Md. (U.S.A.) (Received July 26th, ) SUMMARY Considerable putrescine and Cited by: Polyamines are ubiquitous intracellular cationic amines recognized as participants in cell proliferation and differentiation in many tissues, especially those of intestinal tract development, absorption, and biologic activity, in both sucklings and adults of the species.
The synthesis of polyamines is an active process in the mammary gland. Polyamines are low molecular weight aliphatic polycations, highly charged and ubiquitously present in all living cells.
Interest has been increasing during the last 30 years in the naturally abundant polyamines putrescine (diamine), spermidine (triamine) and spermine (tetramine), which were demonstrated to be involved in a large number of cellular processes.
Polyamines and cancer. Polyamine biosynthesis is up-regulated in actively growing cells, including cancer cells [10,18,19], therefore polyamine concentration as well as gene expression and activity of enzymes involved in polyamine biosynthesis, especially ODC, are higher in cancer tissues than in normal surrounding tissues [8,].Numerous reports have shown that both blood and urine Cited by: COVID Resources.
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tissues and in high concentrations in some microorganisms (1). In mammals, the concentration of spermidine is greatest in tissues with high rates of RXA and protein synthesis, such as pancreas, prostate, bone marrow, regenerating rat liver, lactating mammary gland, and certain tumors (l-3).
The polyamines spermine, spermidine, and putrescine are small organic molecules one or more of which are present in all living organisms.
Many natural products contain polyamine residues. Polyamines are synthesized by a highly regulated pathway from arginine or ornithine and also can be transported in and out of cells. Polyamines are degraded to a variety of compounds the functions of which. Hyperthermic shock induces the synthesis of a novel protein (P71) in many rat tissues in vivo.
In incubated rat tissue slices P71 is the major protein synthesized even though it is undetectable in. POLYAMINE SYNTHESIS. The only polyamines synthesized in mammalian cells are putrescine, spermidine and spermine. Agmatine (decarboxylated arginine) is not produced by mammals but is synthesized by plants and by many bacteria, including the intestinal is possible therefore that it may be derived from food or intestinal microorganisms, although there is an active mammalian Cited by: Pavetamine on protein synthesis in rat tissue ,~ FIG.3 Effect of pavetamine on the synthesis of protein in rat tissues Liver Time (h) FIG.
4 Focal area of myofibrillar lysis. The characteristic band pattern is replaced by predominantly fine myofilaments. The stimulatory influence of polyamines on some kinds of protein synthesis has been established from in vitro experiments with both Escherichia coli and eukaryotic cell-free systems (4–7) and from in vivo experiments with E.
coli polyamine-requiring mutants and bovine polyamine-deficient lymphocytes (8–11).Cited by: Proliferation, Differentiation, and Apoptosis. Polyamines are essential for cell proliferation. Polyamine content is higher in rapidly growing tissues, and regenerative and growth-promoting hormonal stimuli enhance polyamine synthesis and content (15 – 17).Treatment of cultured cells with ODC inhibitors such as α-difluoromethylornithine (DFMO) led to a virtually complete loss of putrescine Cited by: The physiological concentrations of polyamines in plasma, serum and red blood cells were determined in male Wistar rats, using HPLC with fluorometric detection.
The analysis of the metabolic ratio between polyamines and the frontal cortex/plasma relationship for putrescine, spermidine and spermine, suggest the existence of common mechanisms in Cited by: 7.
The role of polyamines in these processes has been poorly expl Influence of physical exercise on polyamine synthesis in the rat skeletal muscle - Turchanowa - - European Journal of Clinical Investigation - Wiley Online LibraryCited by: Polyamines are organic cations found in all eukaryotic cells and intimately involved in, and required for, distinct biological functions.
An increasing body of evidence indicates that the regulation of cellular polyamines is a central convergence point for the multiple signaling pathways driving various cellular functions.
Over the last decade, considerable progress has been made in und. Adult male albino rats were fed diets containing 15% casein and a constant level of inorganic sulfate (%) supplemented with cysteine (%) or methionine (%). The polyamines (putrescine.
been limited by severe host toxicity to renewing tissues, partic ularly the intestinal mucosa. Since the drug is a potent inhibitor of spermidine biosynthesis, the distributions of ornithine and S-adenosylmethionine decarboxylases and polyamine pools have been characterized in the rat intestinal mucosa in anCited by: Synthesis of DNA and methylation of tRNA and ribosomal RNA are also strongly affected by the presence of polyamines [l-5].
Results from several laboratories have pointed to a correlation between levels of polyamines and RNA, not only in bacteria but also in mammalian cells [ 1,2,5]. The state of the art in the area of polyamines is presented in this useful, two-volume publication.
Basic information describing the role of polyamines in the processes of growth and differentiation is given. Also included are data on the regulation of polyamine biosynthesis and metabolism and their. Biogenic amines—polyamines (PAs), particularly putrescine, spermidine and spermine are ubiquitous in all living cells.
Their indispensable roles in many biochemical and physiological processes are becoming commonly known, including promoters of plant life and differential roles in human health and disease. PAs positively impact cellular functions in plants—exemplified by increasing Cited by:.
Polyamines are small organic cations that are essential for normal cell growth and development in eukaryotes. Under normal physiological conditions, intracellular polyamine concentrations are tightly regulated through a dynamic network of biosynthetic and catabolic enzymes, and a poorly characterised transport by: The area of polyamines is presented in this useful, two-volume publication.
Basic information describing the role of polyamines in the processes of growth and differentiation is given. Also included are data on the regulation of polyamine biosynthesis and metabolism and their interactions with nucleic acids.
The use of methylglyoxal-bis(guanylhydrazone) (MGBG) in the clinical treatment of myeloid and lymphoid disorders has been limited by severe host toxicity to renewing tissues, particularly the intestinal mucosa. Since the drug is a potent inhibitor of spermidine biosynthesis, the distributions of ornithine and S -adenosylmethionine decarboxylases and polyamine pools have been characterized in Cited by: